• New paper in Science on the modelling dynamics of human brain cell transplants

    New paper in Science on the modelling dynamics of human brain cell transplants

  • Hippocampal neurons and nerve fibers labelled using Thy1-GFP transgenics

    Hippocampal neurons and nerve fibres labelled using Thy1-GFP transgenics

  • Imaging in vivo of an axon (red) and synaptophysin (green) through a cranial window on postnatal days (PND) 240-310

    Imaging in vivo of an axon (red) and synaptophysin (green) through a cranial window on postnatal days (PND) 240-310

  • Two-photon microscope images of the plasticity of adult cortical synapses <em>in vivo</em> on postnatal days (PND) 98-114

    Two-photon microscope imaging of the plasticity of adult cortical synapses in vivo on postnatal days (PND) 98-114

  • slider-home-CSC-retreat-ND-940x400

  • Microglia (green), brain cell nuclei (red)

    Microglia (green), brain cell nuclei (red)

  • slider-home-Melanie-cx-2-940x400

Welcome to the web site of the Synaptic Plasticity and Repair Group.

We study the plasticity of cortical circuits with the ultimate goal of guiding the development of new therapies for a number of cognitive and age-related disorders.

Latest News

New paper in Science on the modelling dynamics of human brain cell transplants

We have a new collaborative paper in Science on the modelling dynamics of human brain cells transplanted from individuals with and without Downs syndrome into mice. [box style="1"][googlefont font="Trebuchet MS"

Rapid onset form of Wallerian degeneration in the adult neocortex

In a 2-photon imaging tour de force from postdocs Alison Canty and Lieven Huang, the real-time cellular dynamics of axon degeneration in the mammalian brain was investigate. Fundamental differences were

New paper on ageing of the somatosensory cortex

We have a new paper in PLoS One comparing the neuropil ultrastructure and connectivity of aged and adult mice. [box style="1"][googlefont font="Trebuchet MS" size="12px" margin="0px 0px 0px 0px"]The effects of

New collaborative Innovative Training Networks project

Vincenzo De Paola, along with Ramiro Almeida, Catalina Betancur, Daniel Choquet, Ana Luísa Carvalho, Peter Kind, Thomas Knöpfel, Emily Osterweil, Carmen Sandi, Eurotrials, Lundbeck, and The Zeiss Group, is part

New paper on the effect of haloperidol on microglia

Peter Bloomfield’s study on the effect of haloperidol on microglia has been provisionally accepted in Journal of Psychopharmacology. Congratulations Peter!

Carla Pernaci joins the Group

Carla Pernaci, from the Department of Neuroscience "Rita Levi Montalcini" at the University of Turin, Italy, joins the Group as an ERASMUS student. Welcome, Carla!

Galleries

Featured Video: Live Neuron Imaging

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